Answers in Untested Mystery

posted: 12/04/2011

HIV experts in England are puzzled why some people using STI clinics refuse HIV tests. We know for sure that some of those refusing HIV tests do have HIV (from using blood from samples given for syphilis tests and after the syphilis test is done and the blood sample is made completely anonymous, it can be tested for HIV).

The 2009 results from doing this show that 2.4% of gay and bisexual men and 0.25% of heterosexuals tested for syphilis came to the sexual health clinic with undiagnosed HIV.

But only 63% of these people agreed to a HIV test at the STI clinic - much lower than the average rate of HIV testing for people using STI clinics.

Why are so many people who have ‘undiagnosed’ HIV, refusing HIV tests?

One quarter must already know they have HIV - they are taking HIV treatment !

Some useful answers to the testing mystery have now emerged. Now we know that around a quarter of people with ‘undiagnosed’ must know they have HIV, because blood tests prove they are taking HIV treatment. These and other results, given at the British HIV Association conference in Bournemouth last week, are the first clear evidence of some answers to the ‘undiagnosed’ mystery.
 

Slightly more heterosexual women and men (32% for both men and women) than gay men (24%) are using a different clinic for STI checks than for their HIV treatment. Experts thought gay men with HIV were more likely to go elsewhere for HIV checks than heterosexuals. Experts don’t always guess right. Some people with HIV have told community organisations and patient advocates that one reason they go elsewhere for testing is to avoid unwanted, intrusive or judgemental discussion of their sexual behaviour by their own HIV clinic.
 

The results means

• 9 in 100 of the gay and bisexual men who said yes to a syphilis test but no to a HIV test have HIV. At least 2 of those 9 are on treatment but didn’t tell the STI clinic they have HIV
• 8 in 1000 of the heterosexual women and men similarly are HIV positive. At least 2 of those 8 are on treatment but did not tell the STI clinic they have HIV.
   

These findings will make little difference to national estimates of how much undiagnosed HIV there is in the country.
 

Why do gay men who don’t yet know they have HIV refuse HIV tests?
Another small study given to last weeks conference looked at why some gay men refuse HIV tests. Researchers gave an anonymous questionnaire to 19 men who didn’t want to be tested, even though they had had anal sex without condoms and have, either never been tested, or had taken anal sex risks since their last HIV test.

The men could tick more than one reason.
 

15 of the 19 men said they believed they were at low risk of HIV infection [2 of the 19 men knew their partner has HIV]

• 14 said they were emotionally unprepared for a positive result
• 4 said they don’t like giving a blood [but nonetheless gave this to have the syphilis test]
• 4 also mentioned prosecutions for HIV transmission
• 4 said they were planning to test 'next month'
• 3 mentioned worries about the confidentiality of the HIV test result.

Testing Advantages well known

Most of the men know the advantages of HIV testing

• 16 said testing could give peace of mind
• 16 said testing allows treatment to start at the best time.

Testing worries rule

But all the gay men listed the disadvantages to them of HIV testing.

• 17 said testing was stressful
• 8 were worried about having to tell a boyfriend if they were positive
• 7 were concerned about the insurance and mortgage implications.

Unready for positive result, testing stress, in denial about risks

So most of these gay men didn’t feel emotionally ready to deal with a positive result, and find HIV testing stressful.

• Most thought their HIV risk was low, despite having taken enough risks to have got HIV and needing to visit an STI clinic.

The study authors suggest investigating ways of overcoming gay men’s resistance to testing at STI clinics.
 

Source 
Reference – the free conference abstracts - read O13 & P152

Guides for More HIV Testing

posted: 04/04/2011

The number of people who got infected with HIV within the UK in the last 10 years has almost doubled. New infections that happened in the UK (rather than abroad) rose from 1,950 in 2001 to 3,780 in 2010.

In response the National Institute for Clinical Excellence (NICE, the body that tells the NHS what healthcare works and is good value for money) has issued new guidance for the testing of the two groups most at risk of getting HIV in the UK, gay/bi men and African people.

HIV testing helps people keep good health

Testing and treating people with HIV helps the person with HIV stay healthy and to live a near-normal life, helps avoid passing on HIV to others, and can save the NHS a lot of money.
 

The NICE guidance aims to increase the numbers taking HIV tests to reduce the number of people who do not know they have HIV and so help prevent HIV being passed on by Africans living in the UK and gay men.

Gay and bisexual men remain the group most at risk of becoming infected with HIV in the UK with 70 per cent more men being diagnosed with HIV in the past 10 years (from 1,810 in 2001 to 3,080 in 2010).
 

‘NAT welcomes the new NICE guidance on increasing testing among African communities and gay men. Not only is the number of people being diagnosed with HIV still too high, late diagnosis is an extremely important problem as it means a person is likely to have had HIV for a number of years – with a high risk of transmission to sexual partners – and it can also reduce the effectiveness of treatment,” commented Deborah Jack, Chief Executive of NAT (National AIDS Trust).

‘It is crucial that HIV testing becomes ‘normalised’ in our society, not just among gay men and African communities, but also amongst health professionals. Many people with HIV attend NHS services for years without being offered an HIV test and this neglect needs to be addressed and stopped.’

'The importance of HIV testing should now be reflected in Government plans as they reorganise the NHS and public health. In particular, it is essential that HIV late diagnosis remain a key outcome indicator to assess progress in public health at the local level. It is also vital that the extensive reorganisation of the NHS does not undermine recent momentum in HIV testing.’
 

‘Public Health England must ensure that the vision for HIV testing amongst gay men and African communities set out in the NICE Guidance is consistently implemented across the whole of the NHS and public health system.’
 

NICE HIV testing guidance for gay/bi men

NICE testing guidance for Africans living in the UK

Source – HPA press release

Image

GP Guide - Migrants' Health

posted: 26/01/2011

The Migrant Health Guide is a free new online “one stop information shop” for GPs and practice nurses who are working with migrants.

It comes from the Health Protection Agency who have produced it because migrants health needs are often more complex than for other people. HIV is included.

The online guide gives doctors and nurses easy access to the facts, so they can improve their patients’ care and quality of life.
 

Although most migrants to the UK are healthy, TB and HIV and other conditions are more common.

The guide supports diagnosing and managing a range of typical migrant health conditions. Early diagnosis and prompt treatment of HIV and other conditions is important for the health of the individual and to reduce onward transmission.
 

Produced by experts working with primary care practitioners, it comes with the blessings of the Royal College of General Practitioners and the Royal College of Nursing.

Key Recommendations

• Know your local migrant population and their rights to care
• Teach patients how the NHS works
• Assess new patients using the checklist and their country page
• Vaccinate and immunise as normal
• Watch and test for infectious diseases and conditions typical of their country
• Check and advise on any plans to visit friends and relatives abroad.

The Migrant Health Guide has

• detailed information for each country
• tools for assessing migrant patients – new patients, patients with symptoms, identifying more vulnerable patients
• how to talking about the NHS with migrants – explaining it, migrants rights to treatment, languages and interpreters, cultural awareness
• sections about migrant health conditions (including HIV), infectious diseases, vaccinations

Migrant Health Guide

HIV in Primary Care : The best HIV guide for GPs and primary care is (free download) HIV for non-specialists, by MedFash.

HIV in the UK

posted: 03/12/2010

The latest report on HIV in the UK has appeared from the Health Protection Agency. They found  the number of people living with HIV in the UK reached an estimated 86,500. A quarter of these people don’t know they have HIV.
 

New diagnoses among men who have sex with men stayed high (2,760); four out of five gay and bi men probably got HIV in the UK.
 

Of the people newly diagnosed in 2009, 1,130 probably acquired their infection heterosexually, within the UK, accounting for a third of heterosexuals diagnosed.
 

One in six gay and bi men, and one in sixteen heterosexuals got HIV within the previous 4-5 months before their diagnosis.
 

6,600 new people diagnosed

A total of 6,630 people were newly diagnosed as HIV-infected. This represents a fourth year-on-year decline, largely due to fewer diagnoses among people infected heterosexually abroad, mostly in Sub-Saharan Africa – there have been fewer migrants who happen to come from countries with HIV rates of HIV.
 

Older worries

Some 65,000 individuals accessed HIV care, of whom one in five were aged 50 years or over. Since 2000 there has been a three-fold increase in the number of individuals accessing care and a fourfold increase among older (greater than 50 years) individuals.

Sue Peters, regional director of the Terrence Higgins Trust in Brighton, said they are concerned at the number of older people becoming diagnosed in recent years. She pointed out that gay and bi men over 50 have lived through the worst years of HIV and men who remain HIV negative may now feel they are not going to catch it. Some men think that they do catch HIV past their 50th birthday, they are old enough for it not to cause any really serious harm.
“The same issue is with younger people who may still not be aware of the dangers of what is a life long infection. I think people sometimes feel they are immune but they aren’t and it is something that concerns us.”
 

Becoming HIV positive after the age of 50 is not recommended. The immune system becomes less able to fight serious health problems the older we get. People over 50 with HIV tend to be diagnosed late and often need to start HIV treatment immediately. Treatment for HIV becomes more complicated with older age because we often have other long-term health problems to do with being older.

Late too
Half of adults were diagnosed with HIV at a late stage of infection in 2009 (CD4 counts less than 350 within three months of diagnosis), the stage at which treatment is recommended to begin.
 

Thirty-seven English primary care trusts (PCTs) had a prevalence of diagnosed HIV greater than 2 per 1,000 population, the threshold at which expanded HIV testing should be implemented – in NW England these are Manchester, Salford and Blackpool.
 

Uptake of HIV testing was 95% in antenatal clinics and 77% among STI clinic attendees in England.
 

The quality of HIV care received is high. Based on London data, 80% of newly diagnosed patients were seen in an HIV clinic within one month of diagnosis; 90% had an undetectable viral load (less than 50) one year after starting therapy; and 93% of those in care for more than a year had a CD4 count above 200.
 

• HPA recommendations
  
• High proportions of recently acquired HIV infections among newly diagnosed gay and bi men of all age groups underscores the need for ongoing prevention efforts tailored to all ages in this group.
• The national recommendation of universal testing for all attendees of STI clinics should be audited and improved in many clinics; the existing national standard for HIV testing in STI clinics should be reviewed so as to encourage better performance.
• In high prevalence areas (greater than 2 per 1,000 people diagnosed HIV infection) the routine offer and recommendation to accept an HIV test for all adult general practice registrants and general medical admissions should be widely implemented given the recently reported success of pilot projects. The upper age limit for application of this policy should be set with regard to local circumstances.
• Roll-out of clinical outcome indicators to assess the quality of HIV care received by patients, already in place in London, should be extended to the rest of the country.

Sources

Health Protection Agency - HIV in the UK 2010, report and PowerPoint slides

Aidsmap 
 

Brighton Argus

PinkNews

Reduce Numbers Undiagnosed

posted: 15/11/2010

The number of people in England and Wales who do not know they have HIV stayed the same between 2001 and 2008, despite more people being diagnosed with HIV. 

Many of the people with HIV in the UK do not know this yet and undiagnosed people are much more likely to pass on HIV than people who are tested, advised about safer sex and treated.

To prevent onward HIV transmission we need to minimise the number of people with HIV who are undiagnosed and for how long people are undiagnosed.
 

A new study by the Medical Research Council, published in AIDS, estimates the total number of HIV positive people living in England and Wales aged 15-44, both diagnosed and undiagnosed, has increased from 32,400 in 2001 to 54,500 in 2008. Much of this rise is because more people are taking HIV tests.
 

Rise in diagnosed
The proportion of HIV infections diagnosed rose from 58 per cent in 2001 to 71 per cent in 2008, but the estimated number of people with HIV who have not been diagnosed has not fallen, because HIV infections are continuing to happen. Dr Anne Presanis, the leading researcher at the MRC Biostatistics Unit in Cambridge says:
"HIV remains an important public health problem. As long as a large number of people continue to be unaware of their condition, the infection will continue to pass from person to person. These findings highlight the need for continued public health policies aimed at both reducing further HIV transmission and encouraging individuals to get tested and access the help and services they need."
 

Study co-author Professor Noel Gill, head of the Health Protection Agency's HIV & STI department, said:
"The findings of this paper reveal the need to focus efforts on reducing transmission of HIV if we are to bring the overall number of cases down. Early diagnosis of HIV infection will give individuals access to treatment, improve their survival and reduce the risk of transmission to partners. The HPA recommends that people at higher risk of HIV, such as men who have sex with men, should test at least annually for HIV and that everyone should use a condom with all new or casual sexual partners - it is the surest way to ensure you do not become infected with a serious sexually transmitted infection such as HIV."
 

How they did it: triangulating data
The researchers estimated trends in diagnosed and undiagnosed HIV prevalence by putting together different sets of data. They used data on exposure group sizes from behavioural surveys and the population census; on prevalence of total and undiagnosed infection and proportions of infections diagnosed from unlinked anonymous sero-prevalence surveys and community surveys; and on the total number diagnosed from an annual survey of individuals with diagnosed HIV infection. They put these different data together, using a form of statistical "triangulation" of the available data, known as Bayesian multi-parameter evidence synthesis.
 

Source Medical Research Council